# Absorption and Drug Development: Solubility, Permeability, and Charge State, 2nd Edition

Absorption and Drug Development is a reference on solubility, permeability, and charge state, with an emphasis on physicochemical methods for assessing oral drug absorption. This second edition covers topics including PAMPA models, Caco-2/MDCK permeability, blood-brain barrier permeability, and pKa determination.

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- Rating: 5 / 5
- Reviews: 4

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## At a glance

- Discusses physicochemical methods used to investigate drug candidates and their effects on absorption, particularly oral absorption.
- Covers new PAMPA models, Caco-2/MDCK and blood-brain barrier permeability, and methods for pKa determination.
- Includes case studies, examples involving practically insoluble compounds, and expanded database tables.
- The publisher describes more than 200 drawings and over 800 references.

## Pros

- The subject coverage connects solubility, permeability, and charge-state assessment with decisions about drug candidates.
- The publisher describes practical methods, case studies, and visual material alongside references for further research.

## Specifications

### Publication details
- Publisher: Wiley
- Edition: 2nd
- Publication date: May 22, 2012
- Language: English
- Print length: 744 pages
- ISBN-10: 1118057457
- ISBN-13: 978-1118057452
### Dimensions and installation
- Weight listed: 2.63 pounds
- Dimensions: 6.4 x 1.8 x 9.4 inches

## Before you buy

- This is a 2012 second edition. Buyers seeking current research or methods should consider the publication date and verify whether newer material is needed for their work. The listed 744-page length and ISBNs can help identify the intended edition.

## A good fit for

- Pharmaceutical R&D researchers investigating physicochemical properties and drug absorption.
- Graduate students and instructors looking for a supplemental pharmaceutics text.
- Researchers in agrochemical, environmental, and related fields.

## Less suited to

- Readers seeking a general introduction to pharmaceuticals rather than a methods-focused reference.
- Buyers who need a publication reflecting research newer than the 2012 second edition.

## Customer feedback

The available aggregate ratings are uniformly five-star, but the sample is small and no written customer feedback is supplied. That offers limited evidence about reader satisfaction and does not establish how current or useful the methods will be for a particular research need.

## Frequently asked questions

### What topics does this book cover?
It addresses physicochemical methods for investigating drug candidates, with coverage including solubility, permeability, charge state, oral absorption, PAMPA, Caco-2/MDCK, the blood-brain barrier, and pKa determination.
### Who is the book intended for?
The publisher recommends it for pharmaceutical R&D researchers, researchers in agrochemical, environmental, and related fields, and as a supplemental text for graduate pharmaceutics courses.
### How can I confirm this is the intended edition?
The listing identifies it as the second edition, published May 22, 2012, with ISBN-10 1118057457 and ISBN-13 978-1118057452.

## Images

![Absorption and Drug Development: Solubility, Permeability, and Charge State, 2nd Edition — 1](https://best-deals.pro/i/cBY-jCaorL4DZKm4NOgXQNDAjOgtp8b0eXEEVHh1ovAn8CG5kzgkHeKzwdStabNnCcT0vYGxJu1MX1idf8acGzbvoRDAUhdjPTV4263Qhm0s6Yah7bl-.jpg)